Facile synthesis of functionalized tetrahydroquinolines via domino Povarov reactions of arylamines, methyl propiolate and aromatic aldehydes
In the presence of p-toluenesulfonic acid as catalyst the domino reaction of arylamines, methyl propiolates and aromatic aldehydes in ethanol proceeded smoothly to give polysubstituted 1,2,3,4-tetrahydroquinolines in moderate yields. The reaction is believed to involve the Povarov reaction of in sit...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Beilstein-Institut
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511020/ |