Kinetic and thermodynamic characterization of the reaction pathway of box H/ACA RNA-guided pseudouridine formation

Kinetic and thermodynamic characterization of the reaction pathway of box H/ACA RNA-guided pseudouridine formation

The box H/ACA RNA-guided pseudouridine synthase is a complicated ribonucleoprotein enzyme that recruits substrate via both the guide RNA and the catalytic subunit Cbf5. Structural studies have revealed multiple conformations of the enzyme, but a quantitative description of the reaction pathway is st...

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Bibliographic Details
Main Authors: Yang, Xinxing, Duan, Jingqi, Li, Shuang, Wang, Peng, Ma, Shoucai, Ye, Keqiong, Zhao, Xin Sheng
Format: Online
Language:English
Published: Oxford University Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510513/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510513/

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