hMTH1 expression protects mitochondria from Huntington's disease-like impairment

hMTH1 expression protects mitochondria from Huntington's disease-like impairment

Huntington disease (HD) is a neurodegenerative disease caused by expansion of CAG repeats in the huntingtin (Htt) gene. The expression of hMTH1, the human hydrolase that degrades oxidized purine nucleoside triphosphates, grants protection in a chemical HD mouse model in which HD-like features are in...

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Bibliographic Details
Main Authors: Ventura, Ilenia, Russo, Maria Teresa, De Nuccio, Chiara, De Luca, Gabriele, Degan, Paolo, Bernardo, Antonietta, Visentin, Sergio, Minghetti, Luisa, Bignami, Margherita
Format: Online
Language:English
Published: Academic Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507627/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507627/

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