Infectious Complications in Chronic Lymphocytic Leukemia
Infectious complications have been known to be a major cause of morbidity and mortality in Chronic Lymphocytic Leukemia (CLL) patients who are prone to infections because of both the humoral immunodepression inherent to the hematologic disease and to the immunosuppression related to the therapy. The...
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| Format: | Online |
| Language: | English |
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Università Cattolica del Sacro Cuore
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507529/ |
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pubmed-35075292012-11-30 Infectious Complications in Chronic Lymphocytic Leukemia Nosari, Annamaria Review Articles Infectious complications have been known to be a major cause of morbidity and mortality in Chronic Lymphocytic Leukemia (CLL) patients who are prone to infections because of both the humoral immunodepression inherent to the hematologic disease and to the immunosuppression related to the therapy. The majority of infections in CLL patients treated with alkilating agents is of bacterial origin. The immunodeficiency and natural infectious history of alkylator-resistant, corticosteroid-treated patients appears to have changed with the administration of purine analogs, which has been complicated by very severe and unusual infections and also more viral infections due to sustained reduction of CD4-positive T lymphocytes. The subsequent introduction of monoclonal antibodies in therapies, in particular alemtuzumab, further increased the immunodepression, increasing also infections which appeared more often in patients with recurrent neutropenia due to chemotherapy cycles. Università Cattolica del Sacro Cuore 2012-11-05 /pmc/articles/PMC3507529/ /pubmed/23205258 http://dx.doi.org/10.4084/MJHID.2012.070 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Nosari, Annamaria |
| spellingShingle |
Nosari, Annamaria Infectious Complications in Chronic Lymphocytic Leukemia |
| author_facet |
Nosari, Annamaria |
| author_sort |
Nosari, Annamaria |
| title |
Infectious Complications in Chronic Lymphocytic Leukemia |
| title_short |
Infectious Complications in Chronic Lymphocytic Leukemia |
| title_full |
Infectious Complications in Chronic Lymphocytic Leukemia |
| title_fullStr |
Infectious Complications in Chronic Lymphocytic Leukemia |
| title_full_unstemmed |
Infectious Complications in Chronic Lymphocytic Leukemia |
| title_sort |
infectious complications in chronic lymphocytic leukemia |
| description |
Infectious complications have been known to be a major cause of morbidity and mortality in Chronic Lymphocytic Leukemia (CLL) patients who are prone to infections because of both the humoral immunodepression inherent to the hematologic disease and to the immunosuppression related to the therapy. The majority of infections in CLL patients treated with alkilating agents is of bacterial origin. The immunodeficiency and natural infectious history of alkylator-resistant, corticosteroid-treated patients appears to have changed with the administration of purine analogs, which has been complicated by very severe and unusual infections and also more viral infections due to sustained reduction of CD4-positive T lymphocytes. The subsequent introduction of monoclonal antibodies in therapies, in particular alemtuzumab, further increased the immunodepression, increasing also infections which appeared more often in patients with recurrent neutropenia due to chemotherapy cycles. |
| publisher |
Università Cattolica del Sacro Cuore |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507529/ |
| _version_ |
1611935758214496256 |