Laryngeal Involvement of Multiple Myeloma

The objectives of this paper are to discuss a rare cause of laryngeal multiple myeloma, to review unique pathologic findings associated with plasma cell neoplasms, to discuss epidemiology, differential diagnosis, and treatment options for plasma cell neoplasms of the larynx. Laryngeal multiple myelo...

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Main Authors:	Grobman, Ariel B., Vivero, Richard J., Campuzano-Zuluaga, German, Ganjei-Azar, Parvin, Rosow, David E.
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505634/

id	pubmed-3505634
recordtype	oai_dc
spelling	pubmed-35056342012-12-04 Laryngeal Involvement of Multiple Myeloma Grobman, Ariel B. Vivero, Richard J. Campuzano-Zuluaga, German Ganjei-Azar, Parvin Rosow, David E. Case Report The objectives of this paper are to discuss a rare cause of laryngeal multiple myeloma, to review unique pathologic findings associated with plasma cell neoplasms, to discuss epidemiology, differential diagnosis, and treatment options for plasma cell neoplasms of the larynx. Laryngeal multiple myeloma, also noted in the literature as “metastatic” multiple myeloma, presenting as a de novo laryngeal mass is extremely rare with few reported cases. Laryngeal involvement of extramedullary tumors is reported to be between 6% and 18% with the epiglottis, glottis, false vocal folds, aryepiglottic folds, and subglottis involved in decreasing the order of frequency. We present the case of a 58-year-old male with a history of IgA smoldering myeloma who presented to a tertiary care laryngological practice with a two-month history of dysphonia, which was found to be laryngeal involvement of multiple myeloma. We review the classification of and differentiation between different plasma cell neoplasms, disease workups, pathologic findings, and treatment options. Hindawi Publishing Corporation 2012 2012-11-18 /pmc/articles/PMC3505634/ /pubmed/23213583 http://dx.doi.org/10.1155/2012/257814 Text en Copyright © 2012 Ariel B. Grobman et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Grobman, Ariel B. Vivero, Richard J. Campuzano-Zuluaga, German Ganjei-Azar, Parvin Rosow, David E.
spellingShingle	Grobman, Ariel B. Vivero, Richard J. Campuzano-Zuluaga, German Ganjei-Azar, Parvin Rosow, David E. Laryngeal Involvement of Multiple Myeloma
author_facet	Grobman, Ariel B. Vivero, Richard J. Campuzano-Zuluaga, German Ganjei-Azar, Parvin Rosow, David E.
author_sort	Grobman, Ariel B.
title	Laryngeal Involvement of Multiple Myeloma
title_short	Laryngeal Involvement of Multiple Myeloma
title_full	Laryngeal Involvement of Multiple Myeloma
title_fullStr	Laryngeal Involvement of Multiple Myeloma
title_full_unstemmed	Laryngeal Involvement of Multiple Myeloma
title_sort	laryngeal involvement of multiple myeloma
description	The objectives of this paper are to discuss a rare cause of laryngeal multiple myeloma, to review unique pathologic findings associated with plasma cell neoplasms, to discuss epidemiology, differential diagnosis, and treatment options for plasma cell neoplasms of the larynx. Laryngeal multiple myeloma, also noted in the literature as “metastatic” multiple myeloma, presenting as a de novo laryngeal mass is extremely rare with few reported cases. Laryngeal involvement of extramedullary tumors is reported to be between 6% and 18% with the epiglottis, glottis, false vocal folds, aryepiglottic folds, and subglottis involved in decreasing the order of frequency. We present the case of a 58-year-old male with a history of IgA smoldering myeloma who presented to a tertiary care laryngological practice with a two-month history of dysphonia, which was found to be laryngeal involvement of multiple myeloma. We review the classification of and differentiation between different plasma cell neoplasms, disease workups, pathologic findings, and treatment options.
publisher	Hindawi Publishing Corporation
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505634/
_version_	1611935070653775872

Laryngeal Involvement of Multiple Myeloma

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