Cardiomyocyte-restricted overexpression of extracellular superoxide dismutase increases nitric oxide bioavailability and reduces infarct size after ischemia/reperfusion

Cardiomyocyte-restricted overexpression of extracellular superoxide dismutase increases nitric oxide bioavailability and reduces infarct size after ischemia/reperfusion

Increased levels of extracellular superoxide dismutase (ecSOD) induced by preconditioning or gene therapy protect the heart from ischemia/reperfusion injury. To elucidate the mechanism responsible for this action, we studied the effects of increased superoxide scavenging on nitric oxide (NO) bioavai...

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Bibliographic Details
Main Authors: Obal, Detlef, Dai, Shujing, Keith, Rachel, Dimova, Neviana, Kingery, Justin, Zheng, Yu-Ting, Zweier, Jay, Velayutham, Murugesan, Prabhu, Sumanth D., Li, Qianghong, Conklin, Daniel, Yang, Dan, Bhatnagar, Aruni, Bolli, Roberto, Rokosh, Gregg
Format: Online
Language:English
Published: Springer-Verlag 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505528/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505528/

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