Psoriatic Arthritis: An Update
Psoriatic arthritis is a debilitating condition, which affects approximately one-quarter of psoriasis patients. Recent findings have furthered our understanding of the complex pathophysiology of PsA. There have been major advances in the identification of genes associated with joint involvement but...
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| Format: | Online |
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Hindawi Publishing Corporation
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504365/ |
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pubmed-35043652012-12-03 Psoriatic Arthritis: An Update Lloyd, Peter Ryan, Caitriona Menter, Alan Review Article Psoriatic arthritis is a debilitating condition, which affects approximately one-quarter of psoriasis patients. Recent findings have furthered our understanding of the complex pathophysiology of PsA. There have been major advances in the identification of genes associated with joint involvement but not with cutaneous disease alone. The elucidation of key immunologic pathways has allowed the development of novel targeted therapies that are in the research pipeline. Currently, good screening tests and biomarkers to diagnose early PsA and to guide therapy are limited. In this paper, we present recent findings with regard to the immunopathogenesis and genetics of PsA, biomarkers, and screening tools and review the targeted therapies currently in clinical trials. Hindawi Publishing Corporation 2012 2012-10-17 /pmc/articles/PMC3504365/ /pubmed/23209897 http://dx.doi.org/10.1155/2012/176298 Text en Copyright © 2012 Peter Lloyd et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Lloyd, Peter Ryan, Caitriona Menter, Alan |
| spellingShingle |
Lloyd, Peter Ryan, Caitriona Menter, Alan Psoriatic Arthritis: An Update |
| author_facet |
Lloyd, Peter Ryan, Caitriona Menter, Alan |
| author_sort |
Lloyd, Peter |
| title |
Psoriatic Arthritis: An Update |
| title_short |
Psoriatic Arthritis: An Update |
| title_full |
Psoriatic Arthritis: An Update |
| title_fullStr |
Psoriatic Arthritis: An Update |
| title_full_unstemmed |
Psoriatic Arthritis: An Update |
| title_sort |
psoriatic arthritis: an update |
| description |
Psoriatic arthritis is a debilitating condition, which affects approximately one-quarter of psoriasis patients. Recent findings have furthered our understanding of the complex pathophysiology of PsA. There have been major advances in the identification of genes associated with joint involvement but not with cutaneous disease alone. The elucidation of key immunologic pathways has allowed the development of novel targeted therapies that are in the research pipeline. Currently, good screening tests and biomarkers to diagnose early PsA and to guide therapy are limited. In this paper, we present recent findings with regard to the immunopathogenesis and genetics of PsA, biomarkers, and screening tools and review the targeted therapies currently in clinical trials. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504365/ |
| _version_ |
1611934666904829952 |