QTc and QTd in Children with Type 1 Diabetes Mellitus during Diabetic Ketoacidosis
Cardiac arrest has been described in children with diabetic ketoacidosis (DKA). Aim. To evaluate QTc and QTd in type 1 diabetic children with DKA. Methods. Twelve-lead ECG was done to 30 type 1 diabetic children with DKA at presentation and recovery. Corrected QT interval and QT dispersion (QTd) wer...
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International Scholarly Research Network
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503306/ |
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pubmed-35033062012-12-03 QTc and QTd in Children with Type 1 Diabetes Mellitus during Diabetic Ketoacidosis Youssef, Omneya I. Farid, Samar M. Clinical Study Cardiac arrest has been described in children with diabetic ketoacidosis (DKA). Aim. To evaluate QTc and QTd in type 1 diabetic children with DKA. Methods. Twelve-lead ECG was done to 30 type 1 diabetic children with DKA at presentation and recovery. Corrected QT interval and QT dispersion (QTd) were assessed. Results. QTc and QTd mean values were significantly decreased in patients after than before DKA recovery (P < 0.01). Procedure. Sixteen patients (53, 3%) had prolonged QTc during DKA (range 451–538 ms) that dropped to one patient after recovery, his QTc (453 ms) returned to normal 5 days after hospital discharge. Nineteen patients (63.3%) had prolonged QTd (>50 ms) that dropped to three after recovery. The fact that three patients had normal QTc but prolonged QTd increases the privilege of QTd over QTc as a better marker for cardiac risk in those patients. Anion gap was significantly associated with QTc and QTd prolongation (P < 0.0001). Patients had no electrolyte abnormalities or hypoglycemia to account for QTc or QTd prolongation. Conclusion. Prolonged QTc and QTd frequently occur in DKA positively correlated to ketosis. Cardiac monitoring for patients with DKA is mandatory. International Scholarly Research Network 2012-11-06 /pmc/articles/PMC3503306/ /pubmed/23209932 http://dx.doi.org/10.5402/2012/619107 Text en Copyright © 2012 O. I. Youssef and S. M. Farid. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Youssef, Omneya I. Farid, Samar M. |
| spellingShingle |
Youssef, Omneya I. Farid, Samar M. QTc and QTd in Children with Type 1 Diabetes Mellitus during Diabetic Ketoacidosis |
| author_facet |
Youssef, Omneya I. Farid, Samar M. |
| author_sort |
Youssef, Omneya I. |
| title |
QTc and QTd in Children with Type 1 Diabetes Mellitus during Diabetic Ketoacidosis |
| title_short |
QTc and QTd in Children with Type 1 Diabetes Mellitus during Diabetic Ketoacidosis |
| title_full |
QTc and QTd in Children with Type 1 Diabetes Mellitus during Diabetic Ketoacidosis |
| title_fullStr |
QTc and QTd in Children with Type 1 Diabetes Mellitus during Diabetic Ketoacidosis |
| title_full_unstemmed |
QTc and QTd in Children with Type 1 Diabetes Mellitus during Diabetic Ketoacidosis |
| title_sort |
qtc and qtd in children with type 1 diabetes mellitus during diabetic ketoacidosis |
| description |
Cardiac arrest has been described in children with diabetic ketoacidosis (DKA). Aim. To evaluate QTc and QTd in type 1 diabetic children with DKA. Methods. Twelve-lead ECG was done to 30 type 1 diabetic children with DKA at presentation and recovery. Corrected QT interval and QT dispersion (QTd) were assessed. Results. QTc and QTd mean values were significantly decreased in patients after than before DKA recovery (P < 0.01). Procedure. Sixteen patients (53, 3%) had prolonged QTc during DKA (range 451–538 ms) that dropped to one patient after recovery, his QTc (453 ms) returned to normal 5 days after hospital discharge. Nineteen patients (63.3%) had prolonged QTd (>50 ms) that dropped to three after recovery. The fact that three patients had normal QTc but prolonged QTd increases the privilege of QTd over QTc as a better marker for cardiac risk in those patients. Anion gap was significantly associated with QTc and QTd prolongation (P < 0.0001). Patients had no electrolyte abnormalities or hypoglycemia to account for QTc or QTd prolongation. Conclusion. Prolonged QTc and QTd frequently occur in DKA positively correlated to ketosis. Cardiac monitoring for patients with DKA is mandatory. |
| publisher |
International Scholarly Research Network |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503306/ |
| _version_ |
1611934182302285824 |