Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet–Fed Mice

Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet–Fed Mice

The sphingolipids sphingosine-1-phosphate (S1P) and ceramide are important bioactive lipids with many cellular effects. Intracellular ceramide accumulation causes insulin resistance, but sphingosine kinase 1 (SphK1) prevents ceramide accumulation, in part, by promoting its metabolism into S1P. Despi...

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Bibliographic Details
Main Authors: Bruce, Clinton R., Risis, Steve, Babb, Joanne R., Yang, Christine, Kowalski, Greg M., Selathurai, Ahrathy, Lee-Young, Robert S., Weir, Jacquelyn M., Yoshioka, Kazuaki, Takuwa, Yoh, Meikle, Peter J., Pitson, Stuart M., Febbraio, Mark A.
Format: Online
Language:English
Published: American Diabetes Association 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501880/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501880/

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