Spirooxindole Derivative SOID-8 Induces Apoptosis Associated with Inhibition of JAK2/STAT3 Signaling in Melanoma Cells

Spirooxindole Derivative SOID-8 Induces Apoptosis Associated with Inhibition of JAK2/STAT3 Signaling in Melanoma Cells

Melanoma is generally refractory to current chemotherapy, thus new treatment strategies are needed. In this study, we synthesized a series of spirooxindole derivatives (SOID-1 to SOID-12) and evaluated their antitumor effects on melanoma. Among the 12 spirooxindole derivatives, SOID-8 showed the str...

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Bibliographic Details
Main Authors: Tian, Yan, Nam, Sangkil, Liu, Lucy, Yakushijin, Fumiko, Yakushijin, Kenichi, Buettner, Ralf, Liang, Wei, Yang, Fan, Ma, Yuelong, Horne, David, Jove, Richard
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500295/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500295/

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