Analysis of the glutathione S-transferase (GST) gene family
The glutathione S-transferase (GST) gene family encodes genes that are critical for certain life processes, as well as for detoxication and toxification mechanisms, via conjugation of reduced glutathione (GSH) with numerous substrates such as pharmaceuticals and environmental pollutants. The GST gen...
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| Format: | Online |
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BioMed Central
2004
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500200/ |
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pubmed-3500200 |
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pubmed-35002002012-11-17 Analysis of the glutathione S-transferase (GST) gene family Nebert, Daniel W Vasiliou, Vasilis Genome Update The glutathione S-transferase (GST) gene family encodes genes that are critical for certain life processes, as well as for detoxication and toxification mechanisms, via conjugation of reduced glutathione (GSH) with numerous substrates such as pharmaceuticals and environmental pollutants. The GST genes are upregulated in response to oxidative stress and are inexplicably overexpressed in many tumours, leading to problems during cancer chemotherapy. An analysis of the GST gene family in the Human Genome Organization-sponsored Human Gene Nomenclature Committee database showed 21 putatively functional genes. Upon closer examination, however, GST-kappa 1 (GSTK1), prostaglandin E synthase (PTGES) and three microsomal GSTs (MGST1, MGST2, MGST3) were determined as encoding membrane-bound enzymes having GST-like activity, but these genes are not evolutionarily related to the GST gene family. It is concluded that the complete GST gene family comprises 16 genes in six subfamilies -- alpha (GSTA), mu (GSTM), omega (GSTO), pi (GSTP), theta (GSTT) and zeta (GSTZ). BioMed Central 2004-11-01 /pmc/articles/PMC3500200/ /pubmed/15607001 http://dx.doi.org/10.1186/1479-7364-1-6-460 Text en Copyright ©2004 Henry Stewart Publications |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Nebert, Daniel W Vasiliou, Vasilis |
| spellingShingle |
Nebert, Daniel W Vasiliou, Vasilis Analysis of the glutathione S-transferase (GST) gene family |
| author_facet |
Nebert, Daniel W Vasiliou, Vasilis |
| author_sort |
Nebert, Daniel W |
| title |
Analysis of the glutathione S-transferase (GST) gene family |
| title_short |
Analysis of the glutathione S-transferase (GST) gene family |
| title_full |
Analysis of the glutathione S-transferase (GST) gene family |
| title_fullStr |
Analysis of the glutathione S-transferase (GST) gene family |
| title_full_unstemmed |
Analysis of the glutathione S-transferase (GST) gene family |
| title_sort |
analysis of the glutathione s-transferase (gst) gene family |
| description |
The glutathione S-transferase (GST) gene family encodes genes that are critical for certain life processes, as well as for detoxication and toxification mechanisms, via conjugation of reduced glutathione (GSH) with numerous substrates such as pharmaceuticals and environmental pollutants. The GST genes are upregulated in response to oxidative stress and are inexplicably overexpressed in many tumours, leading to problems during cancer chemotherapy. An analysis of the GST gene family in the Human Genome Organization-sponsored Human Gene Nomenclature Committee database showed 21 putatively functional genes. Upon closer examination, however, GST-kappa 1 (GSTK1), prostaglandin E synthase (PTGES) and three microsomal GSTs (MGST1, MGST2, MGST3) were determined as encoding membrane-bound enzymes having GST-like activity, but these genes are not evolutionarily related to the GST gene family. It is concluded that the complete GST gene family comprises 16 genes in six subfamilies -- alpha (GSTA), mu (GSTM), omega (GSTO), pi (GSTP), theta (GSTT) and zeta (GSTZ). |
| publisher |
BioMed Central |
| publishDate |
2004 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500200/ |
| _version_ |
1611924840369881088 |