Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis

Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis

Despite the clinical success of anti-tumor necrosis factor (TNF) therapies in the treatment of inflammatory conditions such as rheumatoid arthritis, Crohn disease and psoriasis, full control of the diseases only occurs in a subset of patients and there is a need for new therapeutics with improved ef...

Full description

Bibliographic Details
Main Authors: Kanakaraj, Palanisamy, Puffer, Bridget A., Yao, Xiao-Tao, Kankanala, Spandana, Boyd, Ernest, Shah, Rutul R., Wang, Geping, Patel, Dimki, Krishnamurthy, Rajesh, Kaithamana, Shashi, Smith, Rodger G., LaFleur, David W., Barbas III, Carlos F., Hilbert, David M., Kiener, Peter A., Roschke, Viktor V.
Format: Online
Language:English
Published: Landes Bioscience 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499301/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499301/

Similar Items