HDAC2 negatively regulates memory formation and synaptic plasticity

HDAC2 negatively regulates memory formation and synaptic plasticity

Chromatin modifications, especially histone-tail acetylation, have been implicated in memory formation. Increased histone-tail acetylation induced by inhibitors of histone deacetylases (HDACis) facilitates learning and memory in wildtype mice as well as in mouse models of neurodegeneration. Harnessi...

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Bibliographic Details
Main Authors: Guan, Ji-Song, Haggarty, Stephen J., Giacometti, Emanuela, Dannenberg, Jan-Hermen, Joseph, Nadine, Gao, Jun, Nieland, Thomas J.F., Zhou, Ying, Wang, Xinyu, Mazitschek, Ralph, Bradner, James E., DePinho, Ronald A., Jaenisch, Rudolf, Tsai, Li-Huei
Format: Online
Language:English
Published: 2009
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498958/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498958/

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