Overcoming multidrug-resistance in vitro and in vivo using the novel P-glycoprotein inhibitor 1416
MDR (multidrug-resistance) represents a major obstacle to successful cancer chemotherapy and is usually accomplished by overexpression of P-gp (P-glycoprotein). Much effort has been devoted to developing P-gp inhibitors to modulate MDR. However, none of the inhibitors on the market have been success...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Portland Press Ltd.
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497725/ |