Expression of a glycosylphosphatidylinositol-anchored ligand, growth hormone, blocks receptor signalling
We have investigated the interaction between GH (growth hormone) and GHR (GH receptor). We previously demonstrated that a truncated GHR that possesses a transmembrane domain but no cytoplasmic domain blocks receptor signalling. Based on this observation we investigated the impact of tethering the re...
| Main Authors: | , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Portland Press Ltd.
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497723/ |