The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae

Expression of the Salmonella effector SteC in yeast leads to down-regulation of the mating and HOG pathways by Cdc42 inhibition. This is mediated by the SteC N-terminal domain through binding to the GEF Cdc24. SteC alters Cdc24 localization and also interacts with human GEF Vav1, suggesting that Ste...

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Main Authors:	Fernandez-Piñar, Pablo, Alemán, Ainel, Sondek, John, Dohlman, Henrik G., Molina, María, Martín, Humberto
Format:	Online
Language:	English
Published:	The American Society for Cell Biology 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496616/

id	pubmed-3496616
recordtype	oai_dc
spelling	pubmed-34966162013-01-30 The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae Fernandez-Piñar, Pablo Alemán, Ainel Sondek, John Dohlman, Henrik G. Molina, María Martín, Humberto Articles Expression of the Salmonella effector SteC in yeast leads to down-regulation of the mating and HOG pathways by Cdc42 inhibition. This is mediated by the SteC N-terminal domain through binding to the GEF Cdc24. SteC alters Cdc24 localization and also interacts with human GEF Vav1, suggesting that SteC could target Cdc42 function in host cells. The American Society for Cell Biology 2012-11-15 /pmc/articles/PMC3496616/ /pubmed/23015760 http://dx.doi.org/10.1091/mbc.E12-03-0243 Text en © 2012 Fernandez-Piñar et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell BD; are registered trademarks of The American Society of Cell Biology.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Fernandez-Piñar, Pablo Alemán, Ainel Sondek, John Dohlman, Henrik G. Molina, María Martín, Humberto
spellingShingle	Fernandez-Piñar, Pablo Alemán, Ainel Sondek, John Dohlman, Henrik G. Molina, María Martín, Humberto The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae
author_facet	Fernandez-Piñar, Pablo Alemán, Ainel Sondek, John Dohlman, Henrik G. Molina, María Martín, Humberto
author_sort	Fernandez-Piñar, Pablo
title	The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae
title_short	The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae
title_full	The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae
title_fullStr	The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae
title_full_unstemmed	The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae
title_sort	salmonella typhimurium effector stec inhibits cdc42-mediated signaling through binding to the exchange factor cdc24 in saccharomyces cerevisiae
description	Expression of the Salmonella effector SteC in yeast leads to down-regulation of the mating and HOG pathways by Cdc42 inhibition. This is mediated by the SteC N-terminal domain through binding to the GEF Cdc24. SteC alters Cdc24 localization and also interacts with human GEF Vav1, suggesting that SteC could target Cdc42 function in host cells.
publisher	The American Society for Cell Biology
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496616/
_version_	1611923781251497984

The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae

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