Regulation of APC/C-Cdh1 and Its Function in Neuronal Survival

Neurons are post-mitotic cells that undergo an active downregulation of cell cycle-related proteins to survive. The activity of the anaphase-promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase that regulates cell cycle progression in proliferating cells, plays a relevant role in post-mitotic...

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Bibliographic Details
Main Author: Almeida, Angeles
Format: Online
Language:English
Published: Humana Press Inc 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496556/