Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus
Heligmosomoides polygyrus is a natural intestinal parasite of mice, which offers an excellent model of the immunology of gastrointestinal helminth infections of humans and livestock. It is able to establish long-term chronic infections in many strains of mice, exerting potent immunomodulatory effect...
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| Format: | Online |
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Springer-Verlag
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496515/ |
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pubmed-3496515 |
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pubmed-34965152012-11-15 Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus Reynolds, Lisa A. Filbey, Kara J. Maizels, Rick M. Review Heligmosomoides polygyrus is a natural intestinal parasite of mice, which offers an excellent model of the immunology of gastrointestinal helminth infections of humans and livestock. It is able to establish long-term chronic infections in many strains of mice, exerting potent immunomodulatory effects that dampen both protective immunity and bystander reactions to allergens and autoantigens. Immunity to the parasite develops naturally in some mouse strains and can be induced in others through immunization; while the mechanisms of protective immunity are not yet fully defined, both antibodies and a host cellular component are required, with strongest evidence for a role of alternatively activated macrophages. We discuss the balance between resistance and susceptibility in this model system and highlight new themes in innate and adaptive immunity, immunomodulation, and regulation of responsiveness in helminth infection. Springer-Verlag 2012-10-11 2012-11 /pmc/articles/PMC3496515/ /pubmed/23053394 http://dx.doi.org/10.1007/s00281-012-0347-3 Text en © The Author(s) 2012 |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Reynolds, Lisa A. Filbey, Kara J. Maizels, Rick M. |
| spellingShingle |
Reynolds, Lisa A. Filbey, Kara J. Maizels, Rick M. Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus |
| author_facet |
Reynolds, Lisa A. Filbey, Kara J. Maizels, Rick M. |
| author_sort |
Reynolds, Lisa A. |
| title |
Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus |
| title_short |
Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus |
| title_full |
Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus |
| title_fullStr |
Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus |
| title_full_unstemmed |
Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus |
| title_sort |
immunity to the model intestinal helminth parasite heligmosomoides polygyrus |
| description |
Heligmosomoides polygyrus is a natural intestinal parasite of mice, which offers an excellent model of the immunology of gastrointestinal helminth infections of humans and livestock. It is able to establish long-term chronic infections in many strains of mice, exerting potent immunomodulatory effects that dampen both protective immunity and bystander reactions to allergens and autoantigens. Immunity to the parasite develops naturally in some mouse strains and can be induced in others through immunization; while the mechanisms of protective immunity are not yet fully defined, both antibodies and a host cellular component are required, with strongest evidence for a role of alternatively activated macrophages. We discuss the balance between resistance and susceptibility in this model system and highlight new themes in innate and adaptive immunity, immunomodulation, and regulation of responsiveness in helminth infection. |
| publisher |
Springer-Verlag |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496515/ |
| _version_ |
1611923726020902912 |