Targeting the right regulatory T-cell population for tumor immunotherapy
Regulatory T cells (Tregs) that suppress tumor-specific T cell-mediated immune responses are the subject of an intense wave of investigation. We recently reported that a subset of Tregs, namely effector/memory CD25low cells, are responsible for suppressing high avidity tumor-specific T cells in mous...
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| Format: | Online |
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Landes Bioscience
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494642/ |
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pubmed-3494642 |
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oai_dc |
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pubmed-34946422012-11-20 Targeting the right regulatory T-cell population for tumor immunotherapy Weiss, Vivian L. Lee, Timothy H. Jaffee, Elizabeth M. Armstrong, Todd D. Author's View Regulatory T cells (Tregs) that suppress tumor-specific T cell-mediated immune responses are the subject of an intense wave of investigation. We recently reported that a subset of Tregs, namely effector/memory CD25low cells, are responsible for suppressing high avidity tumor-specific T cells in mouse mammary tumors. Here, we discuss additional findings that clarify this mechanism of Treg-mediated immunosuppression. Landes Bioscience 2012-10-01 /pmc/articles/PMC3494642/ /pubmed/23170276 http://dx.doi.org/10.4161/onci.20664 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Weiss, Vivian L. Lee, Timothy H. Jaffee, Elizabeth M. Armstrong, Todd D. |
| spellingShingle |
Weiss, Vivian L. Lee, Timothy H. Jaffee, Elizabeth M. Armstrong, Todd D. Targeting the right regulatory T-cell population for tumor immunotherapy |
| author_facet |
Weiss, Vivian L. Lee, Timothy H. Jaffee, Elizabeth M. Armstrong, Todd D. |
| author_sort |
Weiss, Vivian L. |
| title |
Targeting the right regulatory T-cell population for tumor immunotherapy |
| title_short |
Targeting the right regulatory T-cell population for tumor immunotherapy |
| title_full |
Targeting the right regulatory T-cell population for tumor immunotherapy |
| title_fullStr |
Targeting the right regulatory T-cell population for tumor immunotherapy |
| title_full_unstemmed |
Targeting the right regulatory T-cell population for tumor immunotherapy |
| title_sort |
targeting the right regulatory t-cell population for tumor immunotherapy |
| description |
Regulatory T cells (Tregs) that suppress tumor-specific T cell-mediated immune responses are the subject of an intense wave of investigation. We recently reported that a subset of Tregs, namely effector/memory CD25low cells, are responsible for suppressing high avidity tumor-specific T cells in mouse mammary tumors. Here, we discuss additional findings that clarify this mechanism of Treg-mediated immunosuppression. |
| publisher |
Landes Bioscience |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494642/ |
| _version_ |
1611923202566520832 |