Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

Live attenuated SIV vaccines (LAVs) remain the most efficacious of all vaccines in nonhuman primate (NHP) models of HIV/AIDS, yet the basis of their robust protection remains poorly understood. Here, we demonstrate that the degree of LAV-mediated protection against intravenous wildtype SIVmac239 cha...

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Bibliographic Details
Main Authors: Fukazawa, Yoshinori, Park, Haesun, Cameron, Mark J., Lefebvre, Francois, Lum, Richard, Coombes, Noel, Mahyari, Eisa, Hagen, Shoko, Bae, Jin Young, Reyes, Marcelo Delos, Swanson, Tonya, Legasse, Alfred W., Sylwester, Andrew, Hansen, Scott G., Smith, Andrew T., Stafova, Petra, Shoemaker, Rebecca, Li, Yuan, Oswald, Kelli, Axthelm, Michael K., McDermott, Adrian, Ferrari, Guido, Montefiori, David C., Edlefsen, Paul T., Piatak, Michael, Lifson, Jeffrey D., Sékaly, Rafick P., Picker, Louis J.
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493820/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493820/

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