Effect of bone marrow mesenchymal stem cells on experimental pulmonary arterial hypertension
The aim of the present study was to investigate the effect of bone marrow mesenchymal stem cell (BMSC) transp1antation on lung and heart damage in a rat model of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). The animals were randomly divided into 3 groups: control, PAH and BMSC...
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| Format: | Online |
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D.A. Spandidos
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493740/ |
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pubmed-34937402012-12-06 Effect of bone marrow mesenchymal stem cells on experimental pulmonary arterial hypertension ZHANG, ZHAO-HUA LU, YAN LUAN, YUN ZHAO, JING-JIE Articles The aim of the present study was to investigate the effect of bone marrow mesenchymal stem cell (BMSC) transp1antation on lung and heart damage in a rat model of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). The animals were randomly divided into 3 groups: control, PAH and BMSC implantation groups. Structural changes in the pulmonary vascular wall, such as the pulmonary artery lumen area (VA) and vascular area (TAA) were measured by hematoxylin and eosin (H&E) staining, and the hemodynamics were detected by echocardiography. Two weeks post-operation, our results demonstrated that sublingual vein injection of BMSCs significantly attenuated the pulmonary vascular structural and hemodynamic changes caused by pulmonary arterial hypertension. The mechanism may be executed via paracrine effects. D.A. Spandidos 2012-11 2012-08-31 /pmc/articles/PMC3493740/ /pubmed/23226736 http://dx.doi.org/10.3892/etm.2012.691 Text en Copyright © 2012, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
ZHANG, ZHAO-HUA LU, YAN LUAN, YUN ZHAO, JING-JIE |
| spellingShingle |
ZHANG, ZHAO-HUA LU, YAN LUAN, YUN ZHAO, JING-JIE Effect of bone marrow mesenchymal stem cells on experimental pulmonary arterial hypertension |
| author_facet |
ZHANG, ZHAO-HUA LU, YAN LUAN, YUN ZHAO, JING-JIE |
| author_sort |
ZHANG, ZHAO-HUA |
| title |
Effect of bone marrow mesenchymal stem cells on experimental pulmonary arterial hypertension |
| title_short |
Effect of bone marrow mesenchymal stem cells on experimental pulmonary arterial hypertension |
| title_full |
Effect of bone marrow mesenchymal stem cells on experimental pulmonary arterial hypertension |
| title_fullStr |
Effect of bone marrow mesenchymal stem cells on experimental pulmonary arterial hypertension |
| title_full_unstemmed |
Effect of bone marrow mesenchymal stem cells on experimental pulmonary arterial hypertension |
| title_sort |
effect of bone marrow mesenchymal stem cells on experimental pulmonary arterial hypertension |
| description |
The aim of the present study was to investigate the effect of bone marrow mesenchymal stem cell (BMSC) transp1antation on lung and heart damage in a rat model of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). The animals were randomly divided into 3 groups: control, PAH and BMSC implantation groups. Structural changes in the pulmonary vascular wall, such as the pulmonary artery lumen area (VA) and vascular area (TAA) were measured by hematoxylin and eosin (H&E) staining, and the hemodynamics were detected by echocardiography. Two weeks post-operation, our results demonstrated that sublingual vein injection of BMSCs significantly attenuated the pulmonary vascular structural and hemodynamic changes caused by pulmonary arterial hypertension. The mechanism may be executed via paracrine effects. |
| publisher |
D.A. Spandidos |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493740/ |
| _version_ |
1611922943106875392 |