Prediction of Colorectal Cancer Risk Using a Genetic Risk Score: The Korean Cancer Prevention Study-II (KCPS-II)
Colorectal cancer (CRC) is among the leading causes of cancer deaths and can be caused by environmental factors as well as genetic factors. Therefore, we developed a prediction model of CRC using genetic risk scores (GRS) and evaluated the effects of conventional risk factors, including family histo...
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| Format: | Online |
| Language: | English |
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Korea Genome Organization
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492653/ |
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pubmed-3492653 |
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pubmed-34926532012-11-19 Prediction of Colorectal Cancer Risk Using a Genetic Risk Score: The Korean Cancer Prevention Study-II (KCPS-II) Jo, Jaeseong Nam, Chung Mo Sull, Jae Woong Yun, Ji Eun Kim, Sang Yeun Lee, Sun Ju Kim, Yoon Nam Park, Eun Jung Kimm, Heejin Jee, Sun Ha Original Article Colorectal cancer (CRC) is among the leading causes of cancer deaths and can be caused by environmental factors as well as genetic factors. Therefore, we developed a prediction model of CRC using genetic risk scores (GRS) and evaluated the effects of conventional risk factors, including family history of CRC, in combination with GRS on the risk of CRC in Koreans. This study included 187 cases (men, 133; women, 54) and 976 controls (men, 554; women, 422). GRS were calculated with most significantly associated single-nucleotide polymorphism with CRC through a genomewide association study. The area under the curve (AUC) increased by 0.5% to 5.2% when either counted or weighted GRS was added to a prediction model consisting of age alone (AUC 0.687 for men, 0.598 for women) or age and family history of CRC (AUC 0.692 for men, 0.603 for women) for both men and women. Furthermore, the risk of CRC significantly increased for individuals with a family history of CRC in the highest quartile of GRS when compared to subjects without a family history of CRC in the lowest quartile of GRS (counted GRS odds ratio [OR], 47.9; 95% confidence interval [CI], 4.9 to 471.8 for men; OR, 22.3; 95% CI, 1.4 to 344.2 for women) (weighted GRS OR, 35.9; 95% CI, 5.9 to 218.2 for men; OR, 18.1, 95% CI, 3.7 to 88.1 for women). Our findings suggest that in Koreans, especially in Korean men, GRS improve the prediction of CRC when considered in conjunction with age and family history of CRC. Korea Genome Organization 2012-09 2012-09-28 /pmc/articles/PMC3492653/ /pubmed/23166528 http://dx.doi.org/10.5808/GI.2012.10.3.175 Text en Copyright © 2012 by The Korea Genome Organization http://creativecommons.org/licenses/by-nc/3.0 It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Jo, Jaeseong Nam, Chung Mo Sull, Jae Woong Yun, Ji Eun Kim, Sang Yeun Lee, Sun Ju Kim, Yoon Nam Park, Eun Jung Kimm, Heejin Jee, Sun Ha |
| spellingShingle |
Jo, Jaeseong Nam, Chung Mo Sull, Jae Woong Yun, Ji Eun Kim, Sang Yeun Lee, Sun Ju Kim, Yoon Nam Park, Eun Jung Kimm, Heejin Jee, Sun Ha Prediction of Colorectal Cancer Risk Using a Genetic Risk Score: The Korean Cancer Prevention Study-II (KCPS-II) |
| author_facet |
Jo, Jaeseong Nam, Chung Mo Sull, Jae Woong Yun, Ji Eun Kim, Sang Yeun Lee, Sun Ju Kim, Yoon Nam Park, Eun Jung Kimm, Heejin Jee, Sun Ha |
| author_sort |
Jo, Jaeseong |
| title |
Prediction of Colorectal Cancer Risk Using a Genetic Risk Score: The Korean Cancer Prevention Study-II (KCPS-II) |
| title_short |
Prediction of Colorectal Cancer Risk Using a Genetic Risk Score: The Korean Cancer Prevention Study-II (KCPS-II) |
| title_full |
Prediction of Colorectal Cancer Risk Using a Genetic Risk Score: The Korean Cancer Prevention Study-II (KCPS-II) |
| title_fullStr |
Prediction of Colorectal Cancer Risk Using a Genetic Risk Score: The Korean Cancer Prevention Study-II (KCPS-II) |
| title_full_unstemmed |
Prediction of Colorectal Cancer Risk Using a Genetic Risk Score: The Korean Cancer Prevention Study-II (KCPS-II) |
| title_sort |
prediction of colorectal cancer risk using a genetic risk score: the korean cancer prevention study-ii (kcps-ii) |
| description |
Colorectal cancer (CRC) is among the leading causes of cancer deaths and can be caused by environmental factors as well as genetic factors. Therefore, we developed a prediction model of CRC using genetic risk scores (GRS) and evaluated the effects of conventional risk factors, including family history of CRC, in combination with GRS on the risk of CRC in Koreans. This study included 187 cases (men, 133; women, 54) and 976 controls (men, 554; women, 422). GRS were calculated with most significantly associated single-nucleotide polymorphism with CRC through a genomewide association study. The area under the curve (AUC) increased by 0.5% to 5.2% when either counted or weighted GRS was added to a prediction model consisting of age alone (AUC 0.687 for men, 0.598 for women) or age and family history of CRC (AUC 0.692 for men, 0.603 for women) for both men and women. Furthermore, the risk of CRC significantly increased for individuals with a family history of CRC in the highest quartile of GRS when compared to subjects without a family history of CRC in the lowest quartile of GRS (counted GRS odds ratio [OR], 47.9; 95% confidence interval [CI], 4.9 to 471.8 for men; OR, 22.3; 95% CI, 1.4 to 344.2 for women) (weighted GRS OR, 35.9; 95% CI, 5.9 to 218.2 for men; OR, 18.1, 95% CI, 3.7 to 88.1 for women). Our findings suggest that in Koreans, especially in Korean men, GRS improve the prediction of CRC when considered in conjunction with age and family history of CRC. |
| publisher |
Korea Genome Organization |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492653/ |
| _version_ |
1611922508519309312 |