Pgc-1α Overexpression Downregulates Pitx3 and Increases Susceptibility to MPTP Toxicity Associated with Decreased Bdnf

Pgc-1α Overexpression Downregulates Pitx3 and Increases Susceptibility to MPTP Toxicity Associated with Decreased Bdnf

Multiple mechanisms likely contribute to neuronal death in Parkinson’s disease (PD), including mitochondrial dysfunction and oxidative stress. Peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1α) positively regulates the expression of genes required for mitochondrial biogen...

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Bibliographic Details
Main Authors: Clark, Joanne, Silvaggi, Jessica M., Kiselak, Tomas, Zheng, Kangni, Clore, Elizabeth L., Dai, Ying, Bass, Caroline E., Simon, David K.
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492133/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492133/

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