Inherited variants in the MC1R gene and survival from cutaneous melanoma: a BioGenoMEL study

Inherited variants in the MC1R gene and survival from cutaneous melanoma: a BioGenoMEL study

Inherited MC1R variants modulate MITF transcription factor signaling, which in turn affects tumor cell proliferation, apoptosis, and DNA repair. The aim of this BioGenoMEL collaborative study in 10 melanoma cohorts was to test the hypothesis that inherited variants thereby moderate survival expectat...

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Bibliographic Details
Main Authors: Davies, John R, Randerson-Moor, Juliette, Kukalizch, Kairen, Harland, Mark, Kumar, Rajiv, Madhusudan, Srinivasan, Nagore, Eduardo, Hansson, Johan, Höiom, Veronica, Ghiorzo, Paola, Gruis, Nelleke A, Kanetsky, Peter A, Wendt, Judith, Pjanova, Dace, Puig, Susana, Saiag, Philippe, Schadendorf, Dirk, Soufir, Nadem, Okamoto, Ichiro, Affleck, Paul, García-Casado, Zaida, Ogbah, Zighereda, Ozola, Aija, Queirolo, Paola, Sucker, Antje, Barrett, Jennifer H, van Doorn, Remco, Bishop, D Timothy, Newton-Bishop, Julia
Format: Online
Language:English
Published: Blackwell Publishing Ltd 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490389/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490389/

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