Treatment with a Nitric Oxide-Donating NSAID Alleviates Functional Muscle Ischemia in the Mouse Model of Duchenne Muscular Dystrophy

Treatment with a Nitric Oxide-Donating NSAID Alleviates Functional Muscle Ischemia in the Mouse Model of Duchenne Muscular Dystrophy

In patients with Duchenne muscular dystrophy (DMD) and the standard mdx mouse model of DMD, dystrophin deficiency causes loss of neuronal nitric oxide synthase (nNOSĪ¼) from the sarcolemma, producing functional ischemia when the muscles are exercised. We asked if functional muscle ischemia would be e...

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Bibliographic Details
Main Authors: Thomas, Gail D., Ye, Jianfeng, De Nardi, Claudio, Monopoli, Angela, Ongini, Ennio, Victor, Ronald G.
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489726/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489726/

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