Deficits in LTP Induction by 5-HT2A Receptor Antagonist in a Mouse Model for Fragile X Syndrome

Deficits in LTP Induction by 5-HT2A Receptor Antagonist in a Mouse Model for Fragile X Syndrome

Fragile X syndrome is a common inherited form of mental retardation caused by the lack of fragile X mental retardation protein (FMRP) because of Fmr1 gene silencing. Serotonin (5-HT) is significantly increased in the null mutants of Drosophila Fmr1, and elevated 5-HT brain levels result in cognitive...

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Bibliographic Details
Main Authors: Xu, Zhao-hui, Yang, Qi, Ma, Lan, Liu, Shui-bing, Chen, Guang-sheng, Wu, Yu-mei, Li, Xiao-qiang, Liu, Gang, Zhao, Ming-gao
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485341/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485341/

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