Effect of Intensity of Unconditional Stimulus on Reconsolidation of Contextual Fear Memory

Memory reconsolidation is ubiquitous across species and various memory tasks. It is a dynamic process in which memory is modified and/or updated. In experimental conditions, memory reconsolidation is usually characterized by the fact that the consolidated memory is disrupted by a combination of memo...

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Main Authors:	Kwak, Chuljung, Choi, Jun-Hyeok, Bakes, Joseph T., Lee, Kyungmin, Kaang, Bong-Kiun
Format:	Online
Language:	English
Published:	The Korean Physiological Society and The Korean Society of Pharmacology 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484513/

id	pubmed-3484513
recordtype	oai_dc
spelling	pubmed-34845132012-11-01 Effect of Intensity of Unconditional Stimulus on Reconsolidation of Contextual Fear Memory Kwak, Chuljung Choi, Jun-Hyeok Bakes, Joseph T. Lee, Kyungmin Kaang, Bong-Kiun Original Article Memory reconsolidation is ubiquitous across species and various memory tasks. It is a dynamic process in which memory is modified and/or updated. In experimental conditions, memory reconsolidation is usually characterized by the fact that the consolidated memory is disrupted by a combination of memory reactivation and inhibition of protein synthesis. However, under some experimental conditions, the reactivated memory is not disrupted by inhibition of protein synthesis. This so called "boundary condition" of reconsolidation may be related to memory strength. In Pavlovian fear conditioning, the intensity of unconditional stimulus (US) determines the strength of the fear memory. In this study, we examined the effect of the intensity of US on the reconsolidation of contextual fear memory. Strong contextual fear memory, which is conditioned with strong US, is not disrupted by inhibition of protein synthesis after its reactivation; however, a weak fear memory is often disrupted. This suggests that a US of strong intensity can inhibit reconsolidation of contextual fear memory. The Korean Physiological Society and The Korean Society of Pharmacology 2012-10 2012-10-18 /pmc/articles/PMC3484513/ /pubmed/23118552 http://dx.doi.org/10.4196/kjpp.2012.16.5.293 Text en Copyright © 2012 The Korean Physiological Society and The Korean Society of Pharmacology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kwak, Chuljung Choi, Jun-Hyeok Bakes, Joseph T. Lee, Kyungmin Kaang, Bong-Kiun
spellingShingle	Kwak, Chuljung Choi, Jun-Hyeok Bakes, Joseph T. Lee, Kyungmin Kaang, Bong-Kiun Effect of Intensity of Unconditional Stimulus on Reconsolidation of Contextual Fear Memory
author_facet	Kwak, Chuljung Choi, Jun-Hyeok Bakes, Joseph T. Lee, Kyungmin Kaang, Bong-Kiun
author_sort	Kwak, Chuljung
title	Effect of Intensity of Unconditional Stimulus on Reconsolidation of Contextual Fear Memory
title_short	Effect of Intensity of Unconditional Stimulus on Reconsolidation of Contextual Fear Memory
title_full	Effect of Intensity of Unconditional Stimulus on Reconsolidation of Contextual Fear Memory
title_fullStr	Effect of Intensity of Unconditional Stimulus on Reconsolidation of Contextual Fear Memory
title_full_unstemmed	Effect of Intensity of Unconditional Stimulus on Reconsolidation of Contextual Fear Memory
title_sort	effect of intensity of unconditional stimulus on reconsolidation of contextual fear memory
description	Memory reconsolidation is ubiquitous across species and various memory tasks. It is a dynamic process in which memory is modified and/or updated. In experimental conditions, memory reconsolidation is usually characterized by the fact that the consolidated memory is disrupted by a combination of memory reactivation and inhibition of protein synthesis. However, under some experimental conditions, the reactivated memory is not disrupted by inhibition of protein synthesis. This so called "boundary condition" of reconsolidation may be related to memory strength. In Pavlovian fear conditioning, the intensity of unconditional stimulus (US) determines the strength of the fear memory. In this study, we examined the effect of the intensity of US on the reconsolidation of contextual fear memory. Strong contextual fear memory, which is conditioned with strong US, is not disrupted by inhibition of protein synthesis after its reactivation; however, a weak fear memory is often disrupted. This suggests that a US of strong intensity can inhibit reconsolidation of contextual fear memory.
publisher	The Korean Physiological Society and The Korean Society of Pharmacology
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484513/
_version_	1611920009664135168

Effect of Intensity of Unconditional Stimulus on Reconsolidation of Contextual Fear Memory

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