Cytologic Findings of Thyroid Carcinoma Showing Thymus-like Differentiation: A Case Report
Carcinoma showing thymus-like differentiation (CASTLE) is a rare carcinoma of the thyroid or adjacent soft tissue of the neck with a histologic resemblance to thymic epithelial tumors. Although the fine-needle aspiration (FNA) plays a central role in the initial evaluation of thyroid nodules, few re...
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The Korean Society of Pathologists and The Korean Society for Cytopathology
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479772/ |
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pubmed-34797722012-10-29 Cytologic Findings of Thyroid Carcinoma Showing Thymus-like Differentiation: A Case Report Chang, Sunhee Joo, Mee Kim, Hanseong Case Report Carcinoma showing thymus-like differentiation (CASTLE) is a rare carcinoma of the thyroid or adjacent soft tissue of the neck with a histologic resemblance to thymic epithelial tumors. Although the fine-needle aspiration (FNA) plays a central role in the initial evaluation of thyroid nodules, few reports about the cytologic findings of CASTLE have been found according to a review of literatures. We report cytologic findings of a case of CASTLE. A 34-year-old woman presented with a 2-month history of sore throat. The FNA showed that the smear was composed of three dimensional clusters and sheets. The tumor cells were round to ovoid with high nuclear : cytoplasmic ratios. The nuclei were vesicular with small nucleoli. There were some tumor cells showing keratinization. Some lymphocytes were found on the background and within clusters. The presence of poorly-differentiated tumor cells with a focal keratinization and a lymphocytic background on the FNA is suggestive of CASTLE. The Korean Society of Pathologists and The Korean Society for Cytopathology 2012-06 2012-06-22 /pmc/articles/PMC3479772/ /pubmed/23110020 http://dx.doi.org/10.4132/KoreanJPathol.2012.46.3.302 Text en © 2012 The Korean Society of Pathologists/The Korean Society for Cytopathology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Chang, Sunhee Joo, Mee Kim, Hanseong |
| spellingShingle |
Chang, Sunhee Joo, Mee Kim, Hanseong Cytologic Findings of Thyroid Carcinoma Showing Thymus-like Differentiation: A Case Report |
| author_facet |
Chang, Sunhee Joo, Mee Kim, Hanseong |
| author_sort |
Chang, Sunhee |
| title |
Cytologic Findings of Thyroid Carcinoma Showing Thymus-like Differentiation: A Case Report |
| title_short |
Cytologic Findings of Thyroid Carcinoma Showing Thymus-like Differentiation: A Case Report |
| title_full |
Cytologic Findings of Thyroid Carcinoma Showing Thymus-like Differentiation: A Case Report |
| title_fullStr |
Cytologic Findings of Thyroid Carcinoma Showing Thymus-like Differentiation: A Case Report |
| title_full_unstemmed |
Cytologic Findings of Thyroid Carcinoma Showing Thymus-like Differentiation: A Case Report |
| title_sort |
cytologic findings of thyroid carcinoma showing thymus-like differentiation: a case report |
| description |
Carcinoma showing thymus-like differentiation (CASTLE) is a rare carcinoma of the thyroid or adjacent soft tissue of the neck with a histologic resemblance to thymic epithelial tumors. Although the fine-needle aspiration (FNA) plays a central role in the initial evaluation of thyroid nodules, few reports about the cytologic findings of CASTLE have been found according to a review of literatures. We report cytologic findings of a case of CASTLE. A 34-year-old woman presented with a 2-month history of sore throat. The FNA showed that the smear was composed of three dimensional clusters and sheets. The tumor cells were round to ovoid with high nuclear : cytoplasmic ratios. The nuclei were vesicular with small nucleoli. There were some tumor cells showing keratinization. Some lymphocytes were found on the background and within clusters. The presence of poorly-differentiated tumor cells with a focal keratinization and a lymphocytic background on the FNA is suggestive of CASTLE. |
| publisher |
The Korean Society of Pathologists and The Korean Society for Cytopathology |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479772/ |
| _version_ |
1611918393553715200 |