Gastric Adenocarcinoma of Fundic Gland Type: Report of Three Cases

Recently, fundic gland type gastric adenocarcinoma (GA-FG) has been reported as a new entity. This report describes GA-FG among Koreans for the first time. From March 2008 to July 2010 we identified only three cases of GA-FG out of over 6,000 GAs resected by endoscopy or surgery. Cell differentiatio...

Full description

Bibliographic Details
Main Authors:	Park, Eun Su, Kim, Young Eun, Park, Cheol Keun, Yao, Takashi, Kushima, Ryoji, Kim, Kyoung-Mee
Format:	Online
Language:	English
Published:	The Korean Society of Pathologists and The Korean Society for Cytopathology 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479759/

id	pubmed-3479759
recordtype	oai_dc
spelling	pubmed-34797592012-10-29 Gastric Adenocarcinoma of Fundic Gland Type: Report of Three Cases Park, Eun Su Kim, Young Eun Park, Cheol Keun Yao, Takashi Kushima, Ryoji Kim, Kyoung-Mee Case Report Recently, fundic gland type gastric adenocarcinoma (GA-FG) has been reported as a new entity. This report describes GA-FG among Koreans for the first time. From March 2008 to July 2010 we identified only three cases of GA-FG out of over 6,000 GAs resected by endoscopy or surgery. Cell differentiation by mucin proteins, pepsinogen-I, and H+/K+-ATPase was evaluated. All three cases were male patients and diagnosed as early stage GA. Histologically, GA-FGs were well-differentiated adenocarcinoma with pale gray-blue, basophilic columnar or cuboidal cells and mildly enlarged nuclei, resembling chief cells. All three cases were positive for pepsinogen-I and were classified as gastric mucin phenotype. Among three histologic subtypes of GA-FG, since tumors were mainly composed of chief cells, our three cases were classified as chief cell predominant type. In conclusion, GA-FG is very rare among Koreans and pepsinogen-I and MUC6 expression are typical immunohistochemical findings in GA-FG suggesting differentiation toward fundic glands. The Korean Society of Pathologists and The Korean Society for Cytopathology 2012-06 2012-06-22 /pmc/articles/PMC3479759/ /pubmed/23110017 http://dx.doi.org/10.4132/KoreanJPathol.2012.46.3.287 Text en © 2012 The Korean Society of Pathologists/The Korean Society for Cytopathology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Park, Eun Su Kim, Young Eun Park, Cheol Keun Yao, Takashi Kushima, Ryoji Kim, Kyoung-Mee
spellingShingle	Park, Eun Su Kim, Young Eun Park, Cheol Keun Yao, Takashi Kushima, Ryoji Kim, Kyoung-Mee Gastric Adenocarcinoma of Fundic Gland Type: Report of Three Cases
author_facet	Park, Eun Su Kim, Young Eun Park, Cheol Keun Yao, Takashi Kushima, Ryoji Kim, Kyoung-Mee
author_sort	Park, Eun Su
title	Gastric Adenocarcinoma of Fundic Gland Type: Report of Three Cases
title_short	Gastric Adenocarcinoma of Fundic Gland Type: Report of Three Cases
title_full	Gastric Adenocarcinoma of Fundic Gland Type: Report of Three Cases
title_fullStr	Gastric Adenocarcinoma of Fundic Gland Type: Report of Three Cases
title_full_unstemmed	Gastric Adenocarcinoma of Fundic Gland Type: Report of Three Cases
title_sort	gastric adenocarcinoma of fundic gland type: report of three cases
description	Recently, fundic gland type gastric adenocarcinoma (GA-FG) has been reported as a new entity. This report describes GA-FG among Koreans for the first time. From March 2008 to July 2010 we identified only three cases of GA-FG out of over 6,000 GAs resected by endoscopy or surgery. Cell differentiation by mucin proteins, pepsinogen-I, and H+/K+-ATPase was evaluated. All three cases were male patients and diagnosed as early stage GA. Histologically, GA-FGs were well-differentiated adenocarcinoma with pale gray-blue, basophilic columnar or cuboidal cells and mildly enlarged nuclei, resembling chief cells. All three cases were positive for pepsinogen-I and were classified as gastric mucin phenotype. Among three histologic subtypes of GA-FG, since tumors were mainly composed of chief cells, our three cases were classified as chief cell predominant type. In conclusion, GA-FG is very rare among Koreans and pepsinogen-I and MUC6 expression are typical immunohistochemical findings in GA-FG suggesting differentiation toward fundic glands.
publisher	The Korean Society of Pathologists and The Korean Society for Cytopathology
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479759/
_version_	1611918386165448704

Gastric Adenocarcinoma of Fundic Gland Type: Report of Three Cases

Similar Items