GSK3β inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation

GSK3β inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation

This study addresses the role of glycogen synthase kinase (GSK)-3β signaling in the tumorigenic behavior of melanoma. Immunohistochemical staining revealed GSK3β to be focally expressed in the invasive portions of 12% and 33% of primary and metastatic melanomas, respectively. GSK3 inhibitors and siR...

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Bibliographic Details
Main Authors: John, Jobin K., Paraiso, Kim H.T., Rebecca, Vito W., Cantini, Liliana P., Abel, Ethan V., Pagano, Nicholas, Meggers, Eric, Mathew, Rahel, Krepler, Clemens, Izumi, Victoria, Fang, Bin, Koomen, John M., Messina, Jane L., Herlyn, Meenhard, Smalley, Keiran S. M.
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479306/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479306/

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