Rhythmic binding of Topoisomerase I impacts on the transcription of Bmal1 and circadian period
The Bmal1 gene is essential for the circadian system, and its promoter has a unique open chromatin structure. We examined the mechanism of topoisomerase I (Top1) to understand the role of the unique chromatin structure in Bmal1 gene regulation. Camptothecin, a Top1 inhibitor, and Top1 small interfer...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Oxford University Press
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479213/ |