Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78/MTJ-1 Complex

Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78/MTJ-1 Complex

It is unknown whether adipokines derived from adipose tissues modulate endoplasmic reticulum (ER) stress induced in obesity. Here, we show that visceral adipose tissue–derived serine protease inhibitor (vaspin) binds to cell-surface 78-kDa glucose-regulated protein (GRP78), which is recruited from E...

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Bibliographic Details
Main Authors: Nakatsuka, Atsuko, Wada, Jun, Iseda, Izumi, Teshigawara, Sanae, Higashio, Kanji, Murakami, Kazutoshi, Kanzaki, Motoko, Inoue, Kentaro, Terami, Takahiro, Katayama, Akihiro, Hida, Kazuyuki, Eguchi, Jun, Horiguchi, Chikage Sato, Ogawa, Daisuke, Matsuki, Yasushi, Hiramatsu, Ryuji, Yagita, Hideo, Kakuta, Shigeru, Iwakura, Yoichiro, Makino, Hirofumi
Format: Online
Language:English
Published: American Diabetes Association 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478540/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478540/

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