A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

Formation of the death-inducing signaling complex (DISC) is a critical step in death receptor-mediated apoptosis, yet the mechanisms underlying assembly of this key multiprotein complex remain unclear. Using quantitative mass spectrometry, we have delineated the stoichiometry of the native TRAIL DIS...

Full description

Bibliographic Details
Main Authors: Dickens, Laura S., Boyd, Robert S., Jukes-Jones, Rebekah, Hughes, Michelle A., Robinson, Gemma L., Fairall, Louise, Schwabe, John W.R., Cain, Kelvin, MacFarlane, Marion
Format: Online
Language:English
Published: Cell Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477315/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477315/

Similar Items