Concerted action of the PHD, chromo and motor domains regulates the human chromatin remodelling ATPase CHD4
► We dissect the roles of the individual domains of CHD4. ► The chromo domains bind DNA while the PHD domains modulate this activity. ► ATPase and chromo domains increase the histone tail binding affinity of PHD domains. ► PHD and chromo domains are required for DNA stimulated ATPase activity. ► SAX...
| Main Authors: | , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Elsevier Science B.V
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476528/ |