Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr−/− mice fed on a high-fat diet
The propensity of LDLs (low-density lipoproteins) for aggregation and/or oxidation has been linked to their sphingolipid content, specifically the levels of SM (sphingomyelin) and ceramide. To investigate this association in vivo, ldlr (LDL receptor)-null mice (ldlr−/−) were fed on a modified (ather...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Portland Press Ltd.
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475451/ |