Endoplasmic Reticulum Thiol Oxidase Deficiency Leads to Ascorbic Acid Depletion and Noncanonical Scurvy in Mice
Endoplasmic reticulum (ER) thiol oxidases initiate a disulfide relay to oxidatively fold secreted proteins. We found that combined loss-of-function mutations in genes encoding the ER thiol oxidases ERO1α, ERO1β, and PRDX4 compromised the extracellular matrix in mice and interfered with the intracell...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Cell Press
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473360/ |