Degenerate Human Nucleus Pulposus Cells Promote Neurite Outgrowth in Neural Cells

Innervation of nociceptive nerve fibres into the normally aneural nucleus pulposus (NP) of the intervertebral disc (IVD) occurs during degeneration resulting in discogenic back pain. The neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), which are associated with s...

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Bibliographic Details
Main Authors: Richardson, Stephen M., Purmessur, Devina, Baird, Pauline, Probyn, Ben, Freemont, Anthony J., Hoyland, Judith A.
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472988/