Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer

Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer

Ovarian cancer is routinely treated with surgery and platinum-based chemotherapy. Resistance is a major obstacle in the efficacy of this chemotherapy regimen and the ability to identify those patients at risk of developing resistance is of considerable clinical importance. The expression of calpain-...

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Main Authors: Storr, Sarah J, Safuan, Sabreena, Woolston, Caroline M, Abdel-Fatah, Tarek, Deen, Suha, Chan, Stephen Y, Martin, Stewart G
Format: Online
Language:English
Published: Blackwell Publishing Ltd 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472029/
id pubmed-3472029
recordtype oai_dc
spelling pubmed-34720292012-10-18 Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer Storr, Sarah J Safuan, Sabreena Woolston, Caroline M Abdel-Fatah, Tarek Deen, Suha Chan, Stephen Y Martin, Stewart G Original Articles Ovarian cancer is routinely treated with surgery and platinum-based chemotherapy. Resistance is a major obstacle in the efficacy of this chemotherapy regimen and the ability to identify those patients at risk of developing resistance is of considerable clinical importance. The expression of calpain-1, calpain-2 and calpastatin were determined using standard immunohistochemistry on a tissue microarray of 154 primary ovarian carcinomas from patients subsequently treated with platinum-based adjuvant chemotherapy. High levels of calpain-2 expression was significantly associated with platinum resistant tumours (P = 0.031). Furthermore, high expression of calpain-2 was significantly associated with progression-free (P = 0.049) and overall survival (P = 0.006) in this cohort. The association between calpain-2 expression and overall survival remained significant in multivariate analysis accounting for tumour grade, stage, optimal debulking and platinum sensitivity (hazard ratio = 2.174; 95% confidence interval = 1.144–4.130; P = 0.018). The results suggest that determining calpain-2 expression in ovarian carcinomas may allow prognostic stratification of patients treated with surgery and platinum-based chemotherapy. The findings of this study warrant validation in a larger clinical cohort. Blackwell Publishing Ltd 2012-10 2012-09-26 /pmc/articles/PMC3472029/ /pubmed/22435971 http://dx.doi.org/10.1111/j.1582-4934.2012.01559.x Text en Copyright © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Storr, Sarah J
Safuan, Sabreena
Woolston, Caroline M
Abdel-Fatah, Tarek
Deen, Suha
Chan, Stephen Y
Martin, Stewart G
spellingShingle Storr, Sarah J
Safuan, Sabreena
Woolston, Caroline M
Abdel-Fatah, Tarek
Deen, Suha
Chan, Stephen Y
Martin, Stewart G
Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer
author_facet Storr, Sarah J
Safuan, Sabreena
Woolston, Caroline M
Abdel-Fatah, Tarek
Deen, Suha
Chan, Stephen Y
Martin, Stewart G
author_sort Storr, Sarah J
title Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer
title_short Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer
title_full Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer
title_fullStr Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer
title_full_unstemmed Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer
title_sort calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer
description Ovarian cancer is routinely treated with surgery and platinum-based chemotherapy. Resistance is a major obstacle in the efficacy of this chemotherapy regimen and the ability to identify those patients at risk of developing resistance is of considerable clinical importance. The expression of calpain-1, calpain-2 and calpastatin were determined using standard immunohistochemistry on a tissue microarray of 154 primary ovarian carcinomas from patients subsequently treated with platinum-based adjuvant chemotherapy. High levels of calpain-2 expression was significantly associated with platinum resistant tumours (P = 0.031). Furthermore, high expression of calpain-2 was significantly associated with progression-free (P = 0.049) and overall survival (P = 0.006) in this cohort. The association between calpain-2 expression and overall survival remained significant in multivariate analysis accounting for tumour grade, stage, optimal debulking and platinum sensitivity (hazard ratio = 2.174; 95% confidence interval = 1.144–4.130; P = 0.018). The results suggest that determining calpain-2 expression in ovarian carcinomas may allow prognostic stratification of patients treated with surgery and platinum-based chemotherapy. The findings of this study warrant validation in a larger clinical cohort.
publisher Blackwell Publishing Ltd
publishDate 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472029/
_version_ 1611916423307722752

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