Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis

Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis

Many malignancies show increased expression of the EGF receptor family member ErbB3 (HER3). ErbB3 binds beta-1 (HRGβ1), and forms a heterodimer with other ErbB family members, such as ErbB2 (HER2) or EGFR (HER1), enhancing phosphorylation of specific C terminal tyrosine residues and activation of do...

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Bibliographic Details
Main Authors: Smirnova, Tatiana, Zhou, Zhen Ni, Flinn, Rory J., Wyckoff, Jeffrey, Boimel, Pamela J., Pozzuto, Maria, Coniglio, Salvatore J., Backer, Jonathan M., Bresnick, Anne R., Condeelis, John S., Hynes, Nancy E., Segall, Jeffrey E.
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469325/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469325/

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