Proportion of Multidrug-Resistant Tuberculosis in Human Immunodeficiency Virus/Mycobacterium tuberculosis Co-Infected Patients in Korea

Proportion of Multidrug-Resistant Tuberculosis in Human Immunodeficiency Virus/Mycobacterium tuberculosis Co-Infected Patients in Korea

Much controversy surrounds the issue of whether HIV infection is a risk factor for developing multidrug-resistant tuberculosis (MDR-TB). In this study, we evaluated the prevalence of and risk factors for MDR-TB in HIV-infected patients at the National Medical Center of Korea. We reviewed the medical...

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Main Authors: Joh, Joon Sung, Hong, H. Christian, Jeong, In A, Chin, Bum Sik, Yang, Hye Jin, Choi, Hongjo, Bang, Ji Hwan
Format: Online
Language:English
Published: The Korean Academy of Medical Sciences 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468748/
id pubmed-3468748
recordtype oai_dc
spelling pubmed-34687482012-10-22 Proportion of Multidrug-Resistant Tuberculosis in Human Immunodeficiency Virus/Mycobacterium tuberculosis Co-Infected Patients in Korea Joh, Joon Sung Hong, H. Christian Jeong, In A Chin, Bum Sik Yang, Hye Jin Choi, Hongjo Bang, Ji Hwan Original Article Much controversy surrounds the issue of whether HIV infection is a risk factor for developing multidrug-resistant tuberculosis (MDR-TB). In this study, we evaluated the prevalence of and risk factors for MDR-TB in HIV-infected patients at the National Medical Center of Korea. We reviewed the medical records of HIV/TB co-infected patients from January 2005 to May 2011; the drug susceptibility profiles were available for 55 patients. Of these, 32.7% had MDR-TB, which was approximately 3.6 times higher than the prevalence among the general population. Additionally, there were more additional AIDS-defining clinical illnesses in the MDR-TB group than in the non-MDR-TB group (27.8% vs 5.4%, P = 0.032). These results suggest that HIV infection and HIV-related immunosuppresion may contribute to the development of MDR-TB. The Korean Academy of Medical Sciences 2012-10 2012-10-02 /pmc/articles/PMC3468748/ /pubmed/23091309 http://dx.doi.org/10.3346/jkms.2012.27.10.1143 Text en © 2012 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Joh, Joon Sung
Hong, H. Christian
Jeong, In A
Chin, Bum Sik
Yang, Hye Jin
Choi, Hongjo
Bang, Ji Hwan
spellingShingle Joh, Joon Sung
Hong, H. Christian
Jeong, In A
Chin, Bum Sik
Yang, Hye Jin
Choi, Hongjo
Bang, Ji Hwan
Proportion of Multidrug-Resistant Tuberculosis in Human Immunodeficiency Virus/Mycobacterium tuberculosis Co-Infected Patients in Korea
author_facet Joh, Joon Sung
Hong, H. Christian
Jeong, In A
Chin, Bum Sik
Yang, Hye Jin
Choi, Hongjo
Bang, Ji Hwan
author_sort Joh, Joon Sung
title Proportion of Multidrug-Resistant Tuberculosis in Human Immunodeficiency Virus/Mycobacterium tuberculosis Co-Infected Patients in Korea
title_short Proportion of Multidrug-Resistant Tuberculosis in Human Immunodeficiency Virus/Mycobacterium tuberculosis Co-Infected Patients in Korea
title_full Proportion of Multidrug-Resistant Tuberculosis in Human Immunodeficiency Virus/Mycobacterium tuberculosis Co-Infected Patients in Korea
title_fullStr Proportion of Multidrug-Resistant Tuberculosis in Human Immunodeficiency Virus/Mycobacterium tuberculosis Co-Infected Patients in Korea
title_full_unstemmed Proportion of Multidrug-Resistant Tuberculosis in Human Immunodeficiency Virus/Mycobacterium tuberculosis Co-Infected Patients in Korea
title_sort proportion of multidrug-resistant tuberculosis in human immunodeficiency virus/mycobacterium tuberculosis co-infected patients in korea
description Much controversy surrounds the issue of whether HIV infection is a risk factor for developing multidrug-resistant tuberculosis (MDR-TB). In this study, we evaluated the prevalence of and risk factors for MDR-TB in HIV-infected patients at the National Medical Center of Korea. We reviewed the medical records of HIV/TB co-infected patients from January 2005 to May 2011; the drug susceptibility profiles were available for 55 patients. Of these, 32.7% had MDR-TB, which was approximately 3.6 times higher than the prevalence among the general population. Additionally, there were more additional AIDS-defining clinical illnesses in the MDR-TB group than in the non-MDR-TB group (27.8% vs 5.4%, P = 0.032). These results suggest that HIV infection and HIV-related immunosuppresion may contribute to the development of MDR-TB.
publisher The Korean Academy of Medical Sciences
publishDate 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468748/
_version_ 1611915229818519552

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