Odor Memory Stability after Reinnervation of the Olfactory Bulb

Odor Memory Stability after Reinnervation of the Olfactory Bulb

The olfactory system, particularly the olfactory epithelium, presents a unique opportunity to study the regenerative capabilities of the brain, because of its ability to recover after damage. In this study, we ablated olfactory sensory neurons with methimazole and followed the anatomical and functio...

Full description

Bibliographic Details
Main Authors: Blanco-Hernández, Eduardo, Valle-Leija, Pablo, Zomosa-Signoret, Viviana, Drucker-Colín, René, Vidaltamayo, Román
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468571/
id pubmed-3468571
recordtype oai_dc
spelling pubmed-34685712012-10-15 Odor Memory Stability after Reinnervation of the Olfactory Bulb Blanco-Hernández, Eduardo Valle-Leija, Pablo Zomosa-Signoret, Viviana Drucker-Colín, René Vidaltamayo, Román Research Article The olfactory system, particularly the olfactory epithelium, presents a unique opportunity to study the regenerative capabilities of the brain, because of its ability to recover after damage. In this study, we ablated olfactory sensory neurons with methimazole and followed the anatomical and functional recovery of circuits expressing genetic markers for I7 and M72 receptors (M72-IRES-tau-LacZ and I7-IRES-tau-GFP). Our results show that 45 days after methimazole-induced lesion, axonal projections to the bulb of M72 and I7 populations are largely reestablished. Furthermore, regenerated glomeruli are re-formed within the same areas as those of control, unexposed mice. This anatomical regeneration correlates with functional recovery of a previously learned odorant-discrimination task, dependent on the cognate ligands for M72 and I7. Following regeneration, mice also recover innate responsiveness to TMT and urine. Our findings show that regeneration of neuronal circuits in the olfactory system can be achieved with remarkable precision and underscore the importance of glomerular organization to evoke memory traces stored in the brain. Public Library of Science 2012-10-10 /pmc/articles/PMC3468571/ /pubmed/23071557 http://dx.doi.org/10.1371/journal.pone.0046338 Text en © 2012 Blanco-Hernández et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Blanco-Hernández, Eduardo
Valle-Leija, Pablo
Zomosa-Signoret, Viviana
Drucker-Colín, René
Vidaltamayo, Román
spellingShingle Blanco-Hernández, Eduardo
Valle-Leija, Pablo
Zomosa-Signoret, Viviana
Drucker-Colín, René
Vidaltamayo, Román
Odor Memory Stability after Reinnervation of the Olfactory Bulb
author_facet Blanco-Hernández, Eduardo
Valle-Leija, Pablo
Zomosa-Signoret, Viviana
Drucker-Colín, René
Vidaltamayo, Román
author_sort Blanco-Hernández, Eduardo
title Odor Memory Stability after Reinnervation of the Olfactory Bulb
title_short Odor Memory Stability after Reinnervation of the Olfactory Bulb
title_full Odor Memory Stability after Reinnervation of the Olfactory Bulb
title_fullStr Odor Memory Stability after Reinnervation of the Olfactory Bulb
title_full_unstemmed Odor Memory Stability after Reinnervation of the Olfactory Bulb
title_sort odor memory stability after reinnervation of the olfactory bulb
description The olfactory system, particularly the olfactory epithelium, presents a unique opportunity to study the regenerative capabilities of the brain, because of its ability to recover after damage. In this study, we ablated olfactory sensory neurons with methimazole and followed the anatomical and functional recovery of circuits expressing genetic markers for I7 and M72 receptors (M72-IRES-tau-LacZ and I7-IRES-tau-GFP). Our results show that 45 days after methimazole-induced lesion, axonal projections to the bulb of M72 and I7 populations are largely reestablished. Furthermore, regenerated glomeruli are re-formed within the same areas as those of control, unexposed mice. This anatomical regeneration correlates with functional recovery of a previously learned odorant-discrimination task, dependent on the cognate ligands for M72 and I7. Following regeneration, mice also recover innate responsiveness to TMT and urine. Our findings show that regeneration of neuronal circuits in the olfactory system can be achieved with remarkable precision and underscore the importance of glomerular organization to evoke memory traces stored in the brain.
publisher Public Library of Science
publishDate 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468571/
_version_ 1611915172147888128

Similar Items