Enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach

The objective of this research study was to optimize formulation and process variables affecting characteristic of nanosuspension in bead milling process. In this study, the practically water-insoluble telmisartan was nanoground by using top down method i.e. media milling method. Here the media used...

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Main Authors:	Thakar, Divyesh, Bharadia, Praful, Pandya, Vikram
Format:	Online
Language:	English
Published:	Medknow Publications & Media Pvt Ltd 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467830/

id	pubmed-3467830
recordtype	oai_dc
spelling	pubmed-34678302012-10-12 Enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach Thakar, Divyesh Bharadia, Praful Pandya, Vikram Original/Brief The objective of this research study was to optimize formulation and process variables affecting characteristic of nanosuspension in bead milling process. In this study, the practically water-insoluble telmisartan was nanoground by using top down method i.e. media milling method. Here the media used is ZnO2 beads. A variety of surface active agents were tested for their stabilizing effects. Formulation factors evaluated were ratio of polymer to drug, whereas process parameters were milling time and concentration of ZnO2 beads. Different concentration of stabilizers such as poloxamer 188, poloxamer 407, HPMC E 15, PVP K30 and combination of stabilizers were used for preparation of telmisartan nanosuspension. Responses measured in this study include particle size measurement, particle size distribution and zeta potential. Medknow Publications & Media Pvt Ltd 2012-03 /pmc/articles/PMC3467830/ /pubmed/23066201 http://dx.doi.org/10.4103/0975-7406.94137 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Thakar, Divyesh Bharadia, Praful Pandya, Vikram
spellingShingle	Thakar, Divyesh Bharadia, Praful Pandya, Vikram Enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach
author_facet	Thakar, Divyesh Bharadia, Praful Pandya, Vikram
author_sort	Thakar, Divyesh
title	Enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach
title_short	Enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach
title_full	Enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach
title_fullStr	Enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach
title_full_unstemmed	Enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach
title_sort	enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach
description	The objective of this research study was to optimize formulation and process variables affecting characteristic of nanosuspension in bead milling process. In this study, the practically water-insoluble telmisartan was nanoground by using top down method i.e. media milling method. Here the media used is ZnO2 beads. A variety of surface active agents were tested for their stabilizing effects. Formulation factors evaluated were ratio of polymer to drug, whereas process parameters were milling time and concentration of ZnO2 beads. Different concentration of stabilizers such as poloxamer 188, poloxamer 407, HPMC E 15, PVP K30 and combination of stabilizers were used for preparation of telmisartan nanosuspension. Responses measured in this study include particle size measurement, particle size distribution and zeta potential.
publisher	Medknow Publications & Media Pvt Ltd
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467830/
_version_	1611914965104459776

Enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach

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