Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

Small hairpin RNAs (shRNAs) having duplex lengths of 25–29 bp are normally processed by Dicer into short interfering RNAs (siRNAs) before incorporation into the RNA-induced silencing complex (RISC). However, shRNAs of ≤19 bp [short shRNAs (sshRNAs)] are too short for Dicer to excise their loops, rai...

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Bibliographic Details
Main Authors: Dallas, Anne, Ilves, Heini, Ge, Qing, Kumar, Pavan, Shorenstein, Joshua, Kazakov, Sergei A., Cuellar, Trinna L., McManus, Michael T., Behlke, Mark A., Johnston, Brian H.
Format: Online
Language:English
Published: Oxford University Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467060/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467060/

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