Urea–Water Solvation Forces on Prion Structures

Solvation forces are crucial determinants in the equilibrium between the folded and unfolded state of proteins. Particularly interesting are the solvent forces of denaturing solvent mixtures on folded and misfolded states of proteins involved in neurodegeneration. The C-terminal globular domain of t...

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Bibliographic Details
Main Authors: Kleinjung, Jens, Fraternali, Franca
Format: Online
Language:English
Published: American Chemical Society 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466777/