Pharmacological Correctors of Mutant CFTR Mistrafficking
The lack of phenylalanine 508 (ΔF508 mutation) in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) Cl− channel represents the most frequent cause of CF, a genetic disease affecting multiple organs such as lung, pancreas, and liver. ΔF508 causes instability and misfolding of CFTR p...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Frontiers Research Foundation
2012
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464431/ |