Association studies in outbred mice in a new era of full-genome sequencing
Thousands of loci that contribute to quantitative traits in outbred crosses of mice have been reported over the last two decades. In this review we discuss how outbred mouse populations can be used to map and identify the genes and sequence variants that give rise to quantitative variation. We discu...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Springer-Verlag
2012
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463788/ |
| id |
pubmed-3463788 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-34637882012-10-04 Association studies in outbred mice in a new era of full-genome sequencing Yalcin, Binnaz Flint, Jonathan Article Thousands of loci that contribute to quantitative traits in outbred crosses of mice have been reported over the last two decades. In this review we discuss how outbred mouse populations can be used to map and identify the genes and sequence variants that give rise to quantitative variation. We discuss heterogeneous stocks, the diversity outbred, and commercially available outbred populations of mice. All of these populations are descended from a small number of progenitor strains. The availability of the complete sequence of laboratory strains means that in many cases it will be possible to reconstruct the genomes of the outbred animals so that in a genetic association study we can detect the effect of all variants, a situation that has so far eluded studies in completely outbred populations. These resources constitute a major advance and make it possible to progress from a quantitative trait locus to a gene at an unprecedented speed. Springer-Verlag 2012-07-31 2012-10 /pmc/articles/PMC3463788/ /pubmed/22847376 http://dx.doi.org/10.1007/s00335-012-9409-z Text en © The Author(s) 2012 |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Yalcin, Binnaz Flint, Jonathan |
| spellingShingle |
Yalcin, Binnaz Flint, Jonathan Association studies in outbred mice in a new era of full-genome sequencing |
| author_facet |
Yalcin, Binnaz Flint, Jonathan |
| author_sort |
Yalcin, Binnaz |
| title |
Association studies in outbred mice in a new era of full-genome sequencing |
| title_short |
Association studies in outbred mice in a new era of full-genome sequencing |
| title_full |
Association studies in outbred mice in a new era of full-genome sequencing |
| title_fullStr |
Association studies in outbred mice in a new era of full-genome sequencing |
| title_full_unstemmed |
Association studies in outbred mice in a new era of full-genome sequencing |
| title_sort |
association studies in outbred mice in a new era of full-genome sequencing |
| description |
Thousands of loci that contribute to quantitative traits in outbred crosses of mice have been reported over the last two decades. In this review we discuss how outbred mouse populations can be used to map and identify the genes and sequence variants that give rise to quantitative variation. We discuss heterogeneous stocks, the diversity outbred, and commercially available outbred populations of mice. All of these populations are descended from a small number of progenitor strains. The availability of the complete sequence of laboratory strains means that in many cases it will be possible to reconstruct the genomes of the outbred animals so that in a genetic association study we can detect the effect of all variants, a situation that has so far eluded studies in completely outbred populations. These resources constitute a major advance and make it possible to progress from a quantitative trait locus to a gene at an unprecedented speed. |
| publisher |
Springer-Verlag |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463788/ |
| _version_ |
1611913566802149376 |