Development of inflammation-induced hyperalgesia and allodynia is associated with the upregulation of extrasynaptic AMPA receptors in tonically firing lamina II dorsal horn neurons
Persistent peripheral inflammation changes AMPA receptor (AMPAR) trafficking in dorsal horn neurons by promoting internalization of GluR2-containing, Ca2+-impermeable AMPARs from the synapses and by increasing insertion of GluR1-containing, Ca2+-permeable AMPARs in extrasynaptic plasma membrane. The...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462428/ |