c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases

The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands. This pathway, therefore, can act as a critical co...

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Bibliographic Details
Main Authors: Guma, Monica, Firestein, Gary S
Format: Online
Language:English
Published: Bentham Open 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460413/