Translation suppression promotes stress granule formation and cell survival in response to cold shock

Cells respond to stress by inhibition of protein synthesis and subsequent assembly of stress granules (SGs). Cold shock is identified as a novel trigger of SG assembly in yeast and mammals. Cells actively suppress protein synthesis by parallel pathways to induce SG formation and ensure cellular surv...

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Bibliographic Details
Main Authors: Hofmann, Sarah, Cherkasova, Valeria, Bankhead, Peter, Bukau, Bernd, Stoecklin, Georg
Format: Online
Language:English
Published: The American Society for Cell Biology 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459856/