Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential

Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential

Tumor hypoxia induces epithelial-mesenchymal transition (EMT), which induces invasion and metastasis, and is linked to cancer stem cells (CSCs). Whether EMT generates CSCs de novo, enhances migration of existing CSCs or both is unclear. We examined patient tissue of pancreatic ductal adenocarcinoma...

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Bibliographic Details
Main Authors: Salnikov, Alexei V., Liu, Li, Platen, Mitja, Gladkich, Jury, Salnikova, Olga, Ryschich, Eduard, Mattern, Jürgen, Moldenhauer, Gerhard, Werner, Jens, Schemmer, Peter, Büchler, Markus W., Herr, Ingrid
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458836/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458836/

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